Causative Pathways of Preterm Delivery1

Fetal fibronectin is the single common biochemical marker for all 4 mechanisms of preterm birth.

CRH = corticotropin-releasing hormone, CSF = cerebrospinal fluid, E1 = estrone, E2 = estradiol, E3 = estriol, FasL = Fas ligand, HPA = hypothalamic-pituitary-adrenal, IL = interleukin, jct = junction, OT = oxytocin, PG = prostaglandin, PPROM = preterm premature rupture of membrane, TNF = tumor necrosis factor


  1. Lockwood CJ, Kuczynski E. Risk stratification and pathological mechanisms in preterm delivery. Paediatr Perinat Epidemiol. 2001;15(suppl 2):78-89.

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